Refractory Pancytopenia and Megaloblastic Anemia due to Falciparum Malaria

Refractory pancytopenia and megaloblastic anemia due to falciparum malaria.

Anemia is a common complication in malarial infection. Direct destruction and ineffective erythropoesis does not adequately explain the cause of anemia in malaria. We present a case with refractory megaloblastic anemia with asymptomatic falciparum malaria. We hypothesize that promoter variants in the inducible nitric oxide synthase gene might be the cause of severe refractory megaloblastic anem...

Refractory megaloblastic anemia.

Liver extract refractory megaloblastic anemia.

ECENTLY we have had the opportunity to study a patient with a macrocytic anemia and megaloblastic bone marrow, who was refractory to parenteral therapy with vitamin B,2 and refined liver extract, but who responded to folic acid. This type of macrocytic anemia is rare, particularly in this country. Observations made in this case support the concept of a chemical interrelationship between liver e...

Pancytopenia: Megaloblastic Anemia Is Still the Commonest Cause

Objectives: To find out the frequency of the different causes of Pancytopenia and also to specifically detect the percentage of vitamin B12 deficieny amongst these patients. Methodology: It is a prospective study carried out in Medical Unit I (Ward 5) of Jinnah Postgraduate Medical Centre Karachi from March to August 2007. A total of 88 patients were included after a detailed history and examin...

Postpartum aplastic anemia presenting as pancytopenia due to malarial infection.

Pancytopenia is a condition with decreased numbers of all cell lines. Aplastic anemia is a common cause although malarial infection causing lysis of RBCs may also partly mimic this condition. The infection may also damage the patient's bone marrow resulting in pancytopenia as well. We present the case of a post-partum female patient who reported with fever, body aches and shortness of breath on...